Research Interests:

The main research interest of MDIPL is to understand the molecular mechanisms of chronic inflammatory diseases including diabetes, cardiovascular diseases, cancer, asthma and COPD. Research activities in MDIPL strive to understand the inflammatory cascade at the initiation as well as progression level by utilizing both in-vitro and in-vivo experimental models. We study these mechanisms at molecular and cellular levels utilizing advanced biochemical, molecular, cellular and immunological techniques. We strive to perform translational research aimed at identifying new biomarkers for different disease and help identify and develop mechanism-based nontoxic anti-inflammatory therapy for clinical intervention.

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Recent Publications:

1. Rajput PK, Varghese JF, Srivastava AK, Kumar U, Yadav UCS*. Visfatin-induced upregulation of lipogenesis via EGFR/AKT/GSK3β pathway promotes breast cancer cell growth. Cell Signal. 2023 Jul;107:110686. doi: 10.1016/j.cellsig.2023.110686. 

2. Sharma JR, Agraval H, Yadav UCS*. Cigarette smoke induces epithelial-to-mesenchymal transition, stemness, and metastasis in lung adenocarcinoma cells via upregulated RUNX-2/ galectin-3 pathway. Life Sci. 2023 Apr 1;318:121480. doi: 10.1016/j.lfs.2023.121480.

3. Agraval H, Sharma JR, Prakash N, Yadav UCS*. Fisetin suppresses cigarette smoke extract-induced epithelial to mesenchymal transition of airway epithelial cells through regulating COX-2/MMPs/β-catenin pathway. Chem Biol Interact. 2021 Dec 2; 351: 109771. doi: 10.1016/j.cbi.2021.109771.

4. Rather HA, Patel R, Yadav UCS, Vasita R. Dual drug-delivering polycaprolactone-collagen scaffold to induce early osteogenic differentiation and coupled angiogenesis. Biomed Mater. 2020 May 19;15(4):045008. doi: 10.1088/1748-605X/ab7978.

5. Prasad N, Sharma JR, Yadav UCS. Induction of growth cessation by acacetin via β-catenin pathway and apoptosis by apoptosis inducing factor activation in colorectal carcinoma cells. Mol Biol Rep. (2019). Doi: 10.1007/s11033-019-05191-x

6. Agraval H, Yadav UCS*. MMP-2 and MMP-9 mediate cigarette smoke extract-induced epithelial-mesenchymal transition in airway epithelial cells via EGFR/Akt/GSK3β/β-catenin pathway: Amelioration by fisetin. Chem Biol Interact. 2019 Oct 10: 314, 108846. Doi: 10.1016/j.cbi.2019.108846

7. Patel R, Varghese JF, Singh RP, Yadav UCS*. Induction of endothelial dysfunction by oxidized low-density lipoproteins via downregulation of Erk-5/Mef2c/Klf2 signaling: Amelioration by fisetin. Biochimie. 2019 Jun 11; 163: 152-162. DOI. 10.1016/j.biochi.2019.06.007

8. Varghese JF, Patel R, Yadav UCS*. Sterol regulatory element binding protein (SREBP) -1 mediates oxidized low-density lipoprotein (oxLDL) induced macrophage foam cell formation through NLRP3 inflammasome activation. Cellular Signalling. 2019 Jan; 53: 316-326. Doi: 10.1016/j.cellsig.2018.10.020.

9. Dholia N and Yadav UCS*. Lipid mediator Leukotriene D4-induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway. Prostaglandins Other Lipid Mediat. 2018 May; 136:55-63.

10. Rani V, Deep G, Singh RK, Palle K, Yadav UC*. Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies, Life Sciences, Available online 3 February 2016, ISSN 0024-3205, http://dx.doi.org/10.1016/j.lfs.2016.02.002 (*Corresponding Author).